The Mortal Instruments may refer to:
- The Mortal Instruments (book series), the first of The Shadowhunter Chronicles written by Cassandra Clare;
- The Mortal Instruments, Raziel's three gifts that played vital roles to the creations of Shadowhunters;
- The Mortal Instruments: City of Bones, the film adaptation;
- Shadowhunters: The Mortal Instruments, the TV adaptation;
- Simon's band, which has finally settled with the name "The Mortal Instruments".